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In this monograph, the influence of HSAB principle on preference of central metal ions to biologically relevant molecule has been discussed. Taking into account the author’s scientific work on investigations the kinetics and mechanism of interaction between transition metal-based compounds with potential antitumor activity, such as Pt(II), Pd(II) (soft acids) and Zn(II) and Cu(II) (intermediate acids) and biomolecules, a review of the scientific results in this field has been made. Author for more than two decades, investigate substitution processes of monofunctional, bifunctional and dinuclear complexes of platinum(II), palladium(II), lately, zinc(II) and copper(II) with biologically relevant nucleophiles. In this monograph selected results from this field have been reported, considering the high velocity of developments. I hope this monograph will help the researchers and will be catalytic for the students to join research groups which are motivated and engaged in discovery of new knowledges which contribute to expansion of bioinorganic chemistry fields.
Livre de Lyon
metal chemistry, Lewis acid character, Platium based, bioinorganic, anticancer agents
Inorganic Chemistry | Materials Chemistry | Medicinal-Pharmaceutical Chemistry | Organic Chemistry
Soldatović, Tanja V., "Application of The Principle of Hard and Soft Acids and Bases to Mechanisms of Bioinorganic Reactions -Monograph-" (2019). Science and Mathematical Science. 5.